Pinealon 10mg

Description

Pinealon Peptide Overview

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg, developed as part of a family of very short regulatory peptides studied in Russian gerontology research. At three residues it is among the smallest peptides in research use, and its size is central to the mechanism proposed for it.

Short-Peptide Gene Regulation

The hypothesis under investigation is that peptides of this length can enter the nucleus and interact directly with the minor groove of double-stranded DNA at specific sequence motifs, influencing transcription without the receptor intermediary that larger signalling peptides require. Published work has searched systematically for the structural motifs that would make such binding possible.

Neuronal and Oxidative-Stress Models

Most of the experimental literature places Pinealon in neuronal systems, examining cell viability and gene expression under hypoxic or oxidative challenge. These studies are the basis for its use as a tool compound in cellular regulation research.

Synthesis and Purification

Pinealon is produced by solid-phase peptide synthesis and purified by preparative HPLC to analytical grade. Identity and purity are confirmed by HPLC and mass spectrometry, and every vial ships with its batch certificate.

Specifications

• CAS Number: 175175-23-2
• Molecular Formula: C15H26N6O8
• Sequence: Glu-Asp-Arg
• Molar Mass: 418.41 g/mol
• Class: Tripeptide (3 amino acids)
• Storage: Refrigerate after reconstitution. Protect from light and moisture.
• Form: Lyophilized powder in a sterile glass vial.
• Purity: Minimum 99%
• Quantity: 10mg per vial
• Color: White

Important Note: This product is intended solely for in vitro laboratory research by licensed professionals. It is not approved by the FDA for human or animal use and should not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.

References:

1. Khavinson V.Kh. et al. – Peptide regulation of gene expression – Bulletin of Experimental Biology and Medicine
2. Ashapkin V.V. et al. – Epigenetic mechanisms of peptidergic regulation of gene expression during aging – Biochemistry (Moscow)
3. Kolchina N. et al. – Systematic search for structural motifs of peptide binding to double-stranded DNA – Nucleic Acids Research
4. Khavinson V.Kh. & Malinin V.V. – Gerontological Aspects of Genome Peptide Regulation – Karger

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