5-Amino-1MQ 50mg

Description

5-Amino-1MQ Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable and selective inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase). Developed through research originating at the UT Health Science Center around 2017, it is a leading tool compound in the study of metabolism and adipose (fat) biology.

NNMT Inhibition

NNMT transfers a methyl group from SAM (S-adenosylmethionine, the cell’s main methyl donor) onto nicotinamide. 5-Amino-1MQ selectively blocks this enzyme (reported IC50 around 1.2 µM), making it a key research tool for probing NNMT-dependent pathways.

Adipose Metabolism and Energy Expenditure

By inhibiting NNMT, 5-Amino-1MQ is studied for its influence on fat-cell metabolism and cellular energy expenditure, an area of significant interest in metabolic-research models.

SAM Cycling and NAD+ Salvage

Because NNMT consumes both SAM and nicotinamide, blocking it is proposed to affect SAM cycling and the NAD+ salvage pathway — particularly in adipose tissue — linking 5-Amino-1MQ to broader research on cellular energy and NAD+ biology.

Specifications

• CAS Number: 42464-96-0
• Molecular Formula: C10H11N2 (cation); commonly supplied as the chloride salt
• Molar Mass: 159.09 g/mol (free cation)
• Class: Small-molecule NNMT inhibitor
• Storage: Refrigerate after reconstitution.
• Form: Lyophilized powder in a sterile glass vial.
• Purity: Minimum 99%
• Quantity: 50mg per vial
• Color: Off-white to white

Important Note: This product is intended solely for in vitro laboratory research by licensed professionals. It is not approved by the FDA for human or animal use and should not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.

References:

1. Neelakantan H. et al. – Selective and membrane-permeable small-molecule inhibitors of NNMT – Biochemical Pharmacology
2. NNMT as a metabolic regulator in adipose tissue – Nature
3. Kraus D. et al. – Nicotinamide N-methyltransferase knockdown and energy metabolism – Nature
4. 5-Amino-1-methylquinolinium – PubChem (CID 950107)