DSIP (Delta Sleep Inducing Peptide)

Description

DSIP Peptide Overview

DSIP (Delta Sleep Inducing Peptide) is a nonapeptide first isolated in 1977 from the cerebral venous blood of rabbits during induced slow-wave sleep. Its name comes from that original experiment rather than from a settled mechanism; five decades later the peptide remains one of the more unresolved subjects in neuropeptide research, which is part of why it is still studied.

Sleep-Architecture Models

The founding studies reported an increase in delta-wave EEG activity following administration in animal models. Subsequent work has produced mixed results across species and protocols, and current research generally treats the peptide as a modulator rather than a direct sleep-inducing agent.

Neuroendocrine Signalling

Separate from the sleep literature, DSIP has been studied for effects on pituitary hormone release, including reports of altered luteinizing hormone and corticotropin secretion in animal models. Immunoreactive DSIP-like material has been detected in a wide range of peripheral tissues, which complicates any simple central-nervous-system account of the peptide.

Stress and Nociception Research

The peptide also appears in research on stress adaptation, thermoregulation and pain thresholds. Across these areas the reported effects are typically modest and protocol-dependent, and the literature is best read as exploratory.

Specifications

• CAS Number: 62568-57-4
• Molecular Formula: C35H48N10O15
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Molar Mass: 848.81 g/mol
• Class: Nonapeptide (9 amino acids)
• Storage: Refrigerate after reconstitution. Protect from light.
• Form: Lyophilized powder in a sterile glass vial.
• Purity: Minimum 99%
• Quantity: 10mg per vial
• Color: White

Important Note: This product is intended solely for in vitro laboratory research by licensed professionals. It is not approved by the FDA for human or animal use and should not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.

References:

1. Monnier M. & Schoenenberger G.A. – Characterization of a delta-EEG sleep inducing peptide – Pflugers Archiv
2. Graf M.V. & Kastin A.J. – Delta-sleep-inducing peptide (DSIP): a review – Neuroscience and Biobehavioral Reviews
3. Kovalzon V.M. & Strekalova T.V. – Delta sleep-inducing peptide (DSIP): a still unresolved riddle – Journal of Neurochemistry
4. Iyer K.S. & McCann S.M. – Delta sleep inducing peptide (DSIP) and gonadotropin release – Neuroendocrinology

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