Description
MOTS-c Peptide Overview
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region. It is studied in research as a signaling molecule that links mitochondrial function to whole-cell metabolism, and is a leading subject in the emerging field of mitochondrial peptides.
AMPK Pathway Regulation
Under metabolic stress, MOTS-c translocates to the nucleus and is studied as an activator of AMPK, a master regulator of cellular energy. This signaling influences glucose utilization and metabolic flexibility in research models.
Insulin Sensitivity and Metabolic Homeostasis
MOTS-c is investigated for its effects on insulin sensitivity and glucose handling, positioning it as a compound of interest in metabolic-homeostasis research.
Exercise and Aging Research
Research links MOTS-c to exercise physiology and age-related metabolic decline, with studies examining how its levels change with physical activity and aging.
Specifications
- CAS Number: 1627580-64-6
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Ala
- Molar Mass: approx. 2174.6 g/mol
- Class: Mitochondrial-derived peptide (16 amino acids)
- Storage: Refrigerate after reconstitution.
- Form: Lyophilized powder in a sterile glass vial.
- Purity: Minimum 99%
- Quantity: 10mg per vial
- Color: White
Important Note: This product is intended solely for in vitro laboratory research by licensed professionals. It is not approved by the FDA for human or animal use and should not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.
References:
- Lee C. et al. – The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis – Cell Metabolism
- Reynolds J.C. et al. – MOTS-c, exercise and metabolism – Nature Communications
- Mitochondrial-derived peptides in aging – Trends in Endocrinology & Metabolism

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